CNIS Cutaneous Neuro Immune System

• Neurodermatology has given a new impulse into investigating new substances which give an adecuate response to all types of skin problems.
• The CNIS is a new concept at the cutaneous biology level.

• It clarifies the importance of the nervous system and the cutaneous homeostasis.

Neurocosmetics

• The neurocosmetic or "intelligent cosmetic" is the topic application of active ingredients whose neurophysiologic action offers some cosmetics, esthetic and wellness benefits.
• It open a new generation of active ingredients.

Bronzing S.F.

It is a neuropeptide that induces melanogenesis by the activation of the mechanism of action of the alpha-MSH (neurotransmitter).

Mechanism of action

• Activation of the receptor of alpha-HSM through the neuropeptide (Bronzing S.F.).
• Induced stimulation of cAMP for the expressionof tyrosinase, TRP-1 (tyrosinase related protein 1) and DTC (dopachrome taulomerase), enzymes hended fo the production of melanin.

Cosmetic applications:

Selftan